ImageSL analyzes heavy .tif immunohistochemistry slides pixel-by-pixel —
automatically separating true chromogenic staining from background for any color,
quantifying it, and letting you re-render the image exactly how you want to see it.
Free desktop client · your slides are analyzed securely on our servers.
Everything ImageSL does is grounded in real digital-pathology math — then made effortless with AI.
Color deconvolution with automatic Macenko stain-vector estimation isolates the chromogen from the counterstain and glass — for brown DAB or any custom color.
A Claude vision model inspects each slide, identifies the staining, judges tissue quality, and tunes the analysis — reasoning layered on top of exact pixel math.
Generate multiple versions on demand — recolor the background to any code, and make the target staining darker or lighter with a slider.
Ask the ImageSL Assistant anything about your results — it knows your slide's positive-area percentage, thresholds, and optical density, and explains them in plain language.
Pyramidal and multi-page TIFFs are decoded server-side and intelligently downsampled, so multi-gigabyte slides analyze in seconds.
The desktop app is a thin, signed shell. All proprietary logic and keys run remotely — nothing sensitive ever ships inside the download.
Drop a .tif, .tiff, PNG, or JPEG into the app or the web console.
Vision reasoning identifies the stain and the engine separates it pixel-by-pixel.
Get positive-area %, optical density, and an overlay of exactly what was counted.
Recolor, brighten or darken the stain, and ask the assistant to interpret.
ImageSL uses a thin-client architecture. The Windows app you download is a small native shell — it uploads a slide and displays results. Every algorithm and every API key lives on the backend.